Apollo Safety Information
Important safety information for YouthFuel Apollo erectile dysfunction treatments. Read this information carefully before and during treatment.
Active Ingredients
YouthFuel Apollo treatments contain one or more of the following active ingredients, which belong to a class of medications called PDE5 inhibitors. Your provider will prescribe the formulation best suited to your health profile.
Sildenafil
Generic Viagra
Onset: 30-60 minutes
Duration: 4-6 hours
Tadalafil
Generic Cialis
Onset: 30-45 minutes
Duration: Up to 36 hours
Vardenafil
Generic Levitra
Onset: 25-60 minutes
Duration: 4-6 hours
Apollo formulations may also include compound blends tailored to your needs. Your provider will explain the specific ingredients in your prescription.
Contraindications
Do not take PDE5 inhibitors if any of the following apply to you. Disclose all relevant health information during your assessment so your provider can make a safe prescribing decision.
Do NOT take Apollo if you:
- Take nitrates in any form (nitroglycerin, isosorbide mononitrate, isosorbide dinitrate, amyl nitrite/"poppers"). Combining PDE5 inhibitors with nitrates can cause a sudden, severe, and potentially fatal drop in blood pressure.
- Take riociguat (Adempas) or other guanylate cyclase stimulators for pulmonary hypertension.
- Have had a heart attack, stroke, or life-threatening arrhythmia within the past 6 months.
- Have unstable angina, severe heart failure (NYHA Class IV), or uncontrolled high or low blood pressure.
- Have a known hypersensitivity or allergy to sildenafil, tadalafil, vardenafil, or any inactive ingredients.
- Have been advised by a physician to avoid sexual activity due to cardiovascular risk.
- Have severe liver disease (Child-Pugh C) or are on renal dialysis.
- Have retinitis pigmentosa or non-arteritic anterior ischemic optic neuropathy (NAION) history.
Drug Interactions
PDE5 inhibitors can interact with other medications. Always inform your YouthFuel provider of all medications, supplements, and recreational substances you use.
Nitrates and Nitric Oxide Donors
DangerousNitroglycerin, isosorbide, amyl nitrite (poppers). Potentially fatal hypotension. Absolutely contraindicated.
Alpha-Blockers
MajorTamsulosin (Flomax), doxazosin (Cardura), terazosin, prazosin. Can cause significant drops in blood pressure, dizziness, and fainting. Dose adjustments required.
Other Blood Pressure Medications
ModerateAmlodipine, lisinopril, losartan, and other antihypertensives. Additive blood pressure lowering effect. Use with caution and monitoring.
CYP3A4 Inhibitors
ModerateKetoconazole, itraconazole, ritonavir, clarithromycin, erythromycin. Can significantly increase PDE5 inhibitor blood levels, increasing side effect risk. Dose reduction usually required.
Other PDE5 Inhibitors
MajorDo not combine different PDE5 inhibitors (e.g., do not take sildenafil and tadalafil together). Additive effects increase the risk of severe side effects.
Alcohol
ModerateExcessive alcohol use can increase the risk of dizziness, headache, and blood pressure changes. Limit alcohol consumption when taking PDE5 inhibitors.
Grapefruit Juice
MinorMay increase PDE5 inhibitor levels modestly via CYP3A4 inhibition. Use caution with large quantities.
Common Side Effects
Most side effects of PDE5 inhibitors are mild and temporary. They typically diminish as your body adjusts to the medication.
Common (may affect up to 1 in 10 patients)
- Headache
- Facial flushing (warmth or redness)
- Nasal congestion or runny nose
- Indigestion or upset stomach
- Dizziness
- Back pain (more common with tadalafil)
- Muscle aches (more common with tadalafil)
Less Common
- Visual disturbances (blue tint, light sensitivity)
- Blurred vision
- Nausea
- Rash
- Nosebleed
- Insomnia
Serious Side Effects
Stop taking your medication and seek emergency medical attention immediately if you experience any of the following:
- Priapism: An erection lasting more than 4 hours. This is a medical emergency that can cause permanent damage if not treated promptly.
- Sudden vision loss: In one or both eyes, which may be a sign of non-arteritic anterior ischemic optic neuropathy (NAION).
- Sudden hearing loss: With or without ringing in the ears (tinnitus) or dizziness.
- Chest pain or pressure: Especially during or after sexual activity.
- Severe dizziness or fainting: May indicate a dangerous drop in blood pressure.
- Allergic reaction: Difficulty breathing, swelling of face, lips, tongue, or throat, severe rash or hives.
- Seizure: Although extremely rare, seizures have been reported.
Usage Guidelines
- Take only the dose prescribed by your YouthFuel provider. Do not increase your dose without medical guidance.
- Do not take more than one dose in a 24-hour period (or 48-72 hours for tadalafil daily use regimens).
- Sexual stimulation is required for the medication to work. PDE5 inhibitors do not cause an automatic erection.
- Avoid heavy meals (especially high-fat meals) before taking sildenafil or vardenafil, as this may delay onset.
- Store medications at room temperature, away from moisture and direct sunlight.
- Keep medications out of reach of children and pets. Do not share your prescription with anyone.
Questions About Your Treatment?
Contact your YouthFuel care team through your patient portal or reach us directly.
Email: support@youth-fuel.com|Phone: (239) 217-1535
Last updated: March 16, 2026